Lectures and seminars - Weekly overview

 24-03-04 to 24-03-10 

Mon, Mar 04, 2024

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Tue, Mar 05, 2024

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Wed, Mar 06, 2024

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Thu, Mar 07, 2024

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Fri, Mar 08, 2024

MChG-Vortrag, MChG, OC Dept. Chemie
11:15 , Wieland-Hörsaal [BUT-FU1.013 ]

Prof. Dr. Marisa Kozlowski, University of Pennsylvania, College of Arts & Sciences

Oxygen Driven Fragment Coupling for the Synthesis of Natural Products and Antibacterials

Abstract: Nature uses oxidative couplings to construct carbon-carbon, carbon-oxygen, and carbon-nitrogen bonds with a high degree of efficiency. Surprisingly, few laboratory equivalents are as selective or as efficient as the biological versions. The use of parallel microscale screening to discover selective and efficient catalysts for such processes using oxygen as the terminal oxidant will be discussed.  The unexpected outcomes obtained highlight the value of interrogating large numbers of rationally selected variables under the umbrella of general hypothesis. The development of selective oxidative catalytic processes for phenol coupling, enol coupling, and alkyl C–H activation will be discussed. Applications in total synthesis of hypocrellin, honokiol, chaetoglobin, and pyrolaside B will be presented. Finally, studies on the mechanisms of these transformations will be described with the goal of understanding the governing principles and how they might be used to discover further new transformations.

Sat, Mar 09, 2024

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Sun, Mar 10, 2024

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