Projects

Sequence-defined oligo(ethanamino) amides

Nucleic acid based therapeutics

• Development of nonviral vectors
  • Intracellular fate of polyplexes
  • purification of polyplexes
  • biodegradable polycations
  • bioresponsive polyplexes
  • peptide enhanced DNA and RNA delivery
• Targeting Strategies
  • Receptor-ligand interaction
  • transcriptional targeting
  • physical targeting
    • Locoregional Hyperthermia
    • Photo Chemical Internalization (PCI)

Therapeutic Strategies

• Synthetic double stranded RNA for Glioblastoma treatment
• Tumor Angiogenesis
• Culture Models of Colorectal Cancer

Supplementary material for Boeckle et al, 2005

• low res. Video (mpeg, 0.6 MB)
• high res. Video (avi, 33 MB)

Fighting Cancer by Overcoming Chemoresistance and Preventing Metastasis

• Novel Mechanisms of Chemoresistance
• Combinatorial Treatment - Targeting Cancer Stem Cells
• miRNAs involved in chemoresistance

Supplemental videos for Kopp et al, 2013

• MDA-MB control.avi
• MDA-MB doxorubicin.avi
• MDA-MB salinomycin.avi

Supplemental videos for Ljepoja et al, 2019

• SM1-Ctrl stack
• SM2-miR-200c stack
• SM3-1D migration